Understanding how genetics influences complex diseases in different populations
Characterizing the evolutionary architecture of complex disease within and across diverse populations
This study is looking at how our genes can affect complex diseases by examining data from different ethnic groups, so we can better understand health risks and create more personalized treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10873762 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to complex diseases by analyzing data from diverse populations. It utilizes genome-wide association studies (GWAS) to identify genetic variants associated with various health conditions, focusing on how these variants differ across ethnic groups. By integrating multi-ethnic data, the research aims to improve the understanding of disease risks and the evolutionary mechanisms that shape these genetic variations. Patients may benefit from insights that could lead to more personalized and effective treatments based on their genetic background.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from various ethnic backgrounds who are at risk for complex diseases.
Not a fit: Patients with rare genetic disorders or those not represented in diverse population studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of complex diseases tailored to diverse populations.
How similar studies have performed: Previous studies using multi-ethnic GWAS data have shown promising results in identifying causal factors for complex traits, indicating this approach has potential for success.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Mancuso, Nicholas — University of Southern California
- Study coordinator: Mancuso, Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.