Understanding how genetics influence tuberculosis outcomes through granuloma biology
Linking Human TB Genetic Susceptibility Loci to Granuloma Biology
This study is looking at how our genes influence how our bodies fight tuberculosis, especially focusing on a part of the immune response called granulomas, and it aims to find new ways to help people with this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11005728 on NIH RePORTER |
What this research studies
This research investigates how specific genetic factors in humans affect the body's response to tuberculosis, particularly focusing on the granuloma, a structure that plays a crucial role in the disease's progression. By using various animal models, including mice and zebrafish, the study aims to explore the cellular and molecular dynamics of granulomas and how they relate to different disease outcomes. The researchers will analyze gene expression and immune responses to better understand the mechanisms behind tuberculosis susceptibility and disease severity. This work could lead to new insights into how to combat tuberculosis more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a known genetic predisposition to tuberculosis or those who have been exposed to the bacteria.
Not a fit: Patients who do not have any genetic factors associated with tuberculosis susceptibility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating tuberculosis based on individual genetic susceptibility.
How similar studies have performed: Previous research has shown promising results in linking genetic factors to disease outcomes in other infectious diseases, suggesting potential for success in this area as well.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Tobin, David M. — Duke University
- Study coordinator: Tobin, David M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.