Understanding how genetics influence the effects of alcohol exposure during pregnancy
Characterizing the Genetics of FASD in Complementary Mouse and Fish Models
This study is looking at how our genes might influence the effects of drinking alcohol during pregnancy on babies, using animal models to help us understand why some children are more affected than others by fetal alcohol spectrum disorders (FASD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10928805 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to fetal alcohol spectrum disorders (FASD) caused by alcohol exposure during pregnancy. By using advanced techniques such as CRISPR gene editing and next-generation sequencing, the study aims to identify specific genes and pathways that affect how different individuals respond to prenatal alcohol exposure. The research utilizes various animal models, including mice and zebrafish, to explore these genetic influences in a controlled environment. This approach allows for a deeper understanding of the variability in FASD outcomes among affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with a history of prenatal alcohol exposure or those diagnosed with fetal alcohol spectrum disorders.
Not a fit: Patients who have not been exposed to alcohol during pregnancy or do not have any related developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and treatments for individuals affected by fetal alcohol spectrum disorders.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to FASD using similar methodologies, indicating a potential for success in this approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Parnell, Scott — Univ of North Carolina Chapel Hill
- Study coordinator: Parnell, Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.