Understanding how genetics influence recovery from blast-induced brain injuries
Official title: SDR: Genomic analysis of blast tube induced TBI in mice
Funded at VA New Jersey Health Care System · NIH-11171321 · Data updated 2026-11-12
This study is looking at how our genes might influence how well military personnel recover from brain injuries caused by blasts, using mice to help find out which genes make some people more vulnerable or more resilient, with the hope of improving treatments for veterans dealing with long-term effects of these injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA New Jersey Health Care System NIH-funded |
| Lab location | 1 site (East Orange, United States) |
| Project start | January 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX005015-06 |
| Project ID | NIH-11171321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are veterans or individuals with a history of traumatic brain injury, particularly those exposed to blast waves.
✕Less likely to help
Patients who have not experienced traumatic brain injuries or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors that affect recovery from traumatic brain injuries (TBI) caused by blast exposure, particularly in military personnel. By using a blast tube system to simulate the pressure waves from explosions, researchers will study various mouse strains to identify genes that contribute to either susceptibility to brain damage or resilience and recovery. Behavioral tests will be conducted before and after the injury to assess functional outcomes and the role of genetics in recovery. The goal is to enhance personalized treatment approaches for veterans suffering from long-term effects of TBI.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for veterans and others affected by blast-induced brain injuries.
How similar studies have gone: While the specific genetic approach to TBI recovery is relatively novel, similar studies have shown promise in understanding genetic influences on recovery from other types of brain injuries.
Where this research is happening
-
VA New Jersey Health Care System
East Orange, United States Active
Researchers
- Principal investigator: Citron, Bruce a. — VA New Jersey Health Care System
- Study coordinator: Citron, Bruce a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.