Understanding how genetics influence oxycodone use in rats.
Genetics of oxycodone intake in a hybrid rat diversity panel.
['FUNDING_U01'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-11013855
This study is looking at how our genes might affect how much oxycodone people take, which could help us understand why some individuals are more likely to become addicted to opioids, and it’s aimed at anyone interested in the science behind addiction and treatment options.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11013855 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that may influence the intake of oxycodone, a commonly abused prescription opioid, using a diverse panel of rat genomes. By modeling the way humans typically consume oxycodone, the study aims to identify specific genetic variants that could predispose individuals to opioid addiction. The researchers will employ advanced techniques, including whole genome sequencing and multi-omics data analysis, to explore the interactions between genes, drug exposure, and environmental factors. This work could provide insights into the biological underpinnings of addiction and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals with a family history of opioid addiction or those who have experienced issues with opioid use.
Not a fit: Patients who do not have a history of opioid use or addiction may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic risk factors for opioid addiction, potentially guiding personalized treatment approaches for patients.
How similar studies have performed: Other research has shown success in identifying genetic factors related to substance use disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHARP, BURT M — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: SHARP, BURT M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder