Understanding how genetics influence immune system development and diseases
Dissecting dynamic genetic effects from thymus development to immune-mediated disease
This study is looking at how our genes affect the development of immune cells in kids and how this might relate to diseases later in life, using samples from children's thymus and blood to better understand these connections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-11076633 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that affect the development of T cells in the thymus and their role in immune-mediated diseases, particularly during childhood. By analyzing pediatric thymus samples and peripheral immune cells, the study aims to uncover how genetic variations influence immune responses and disease susceptibility. The approach involves advanced techniques like single-cell gene expression quantitative trait mapping to provide insights into the relationship between genetics and immune function. This research seeks to bridge the gap in understanding how childhood immune characteristics can impact health in adulthood.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young adults with autoimmune conditions or those at risk for developing such diseases.
Not a fit: Patients with autoimmune diseases that are not influenced by genetic factors or those outside the age range of 21 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of autoimmune diseases, particularly in children and young adults.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on immune responses, but this specific focus on childhood development and autoimmune diseases is relatively novel.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Meyer, Hannah Verena — Cold Spring Harbor Laboratory
- Study coordinator: Meyer, Hannah Verena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.