Understanding how genetics influence immune responses to tuberculosis in a diverse Peruvian population
Characterizing the Genomic Basis of Immune-Mediated Resilience Against Tuberculosis in an Admixed Peruvian Population
['FUNDING_FELLOWSHIP'] · HARVARD MEDICAL SCHOOL · NIH-10898048
This study is looking at how our genes might influence how we respond to tuberculosis, especially in people from Lima, Peru, to help find better ways to treat and support those affected by the disease.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10898048 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that affect how individuals respond to tuberculosis (TB), particularly focusing on a population in Lima, Peru, which has a high burden of the disease. By analyzing the genetic makeup and immune responses of patients, the study aims to identify specific immune phenotypes that are influenced by genetic ancestry. The approach includes advanced techniques such as transcriptional profiling of immune cells and single-cell analysis, which will help uncover the complex interactions between genetics and immune function in TB progression. This research is crucial for developing targeted interventions and improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from Lima, Peru, particularly those with a history of tuberculosis exposure or infection.
Not a fit: Patients who do not have a genetic background related to the Peruvian population or those who are not affected by tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment strategies for tuberculosis, potentially reducing its impact on vulnerable populations.
How similar studies have performed: Previous research has shown success in identifying genetic factors influencing disease progression in other populations, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUMKER, LAURIE ANN — HARVARD MEDICAL SCHOOL
- Study coordinator: RUMKER, LAURIE ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Communicable Diseases