Understanding how genetics influence brain health after radiation therapy for cancer
Investigating the role of ApoE4 and amyloid beta in susceptibility to neurologic complications after brain radiotherapy
This study is looking at how a specific gene, called ApoE4, might affect memory and thinking skills in older adults who have had radiation therapy for cancer, with the hope of finding ways to help protect their brain function, especially if they are at risk for Alzheimer’s disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10288163 on NIH RePORTER |
What this research studies
This research investigates the impact of genetic factors, specifically the ApoE4 variant, on cognitive decline in older adults who have undergone brain radiation therapy for cancer. By examining the relationship between Alzheimer’s disease and the neurological effects of cancer treatments, the study aims to uncover mechanisms that lead to cognitive dysfunction. The approach includes using models of Alzheimer’s disease to explore how these genetic predispositions may exacerbate cognitive decline after treatment. The ultimate goal is to develop strategies that can protect brain function in patients at risk for Alzheimer’s disease who are receiving cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those with a genetic predisposition to Alzheimer’s disease who have received or are scheduled to receive brain radiation therapy.
Not a fit: Patients who are younger than 21 years old or those without a genetic risk for Alzheimer’s disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies that help preserve cognitive function in older adults undergoing cancer treatment.
How similar studies have performed: Previous research has shown that genetic factors can influence cognitive outcomes in various populations, suggesting that this approach may yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Nakamura, Jean — University of California, San Francisco
- Study coordinator: Nakamura, Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.