Understanding how genetics influence blood clotting factors
Official title: Analysis of Whole Genome Sequence and Hemostasis Phenotypes
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10849923 · Data updated 2026-11-12
This study is looking at how our genes affect important proteins that help our blood clot, specifically in a diverse group of 14,000 Hispanic people, to better understand blood clotting issues and improve health for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $640,459 |
| NIH project number | 5R01HL139553-05 |
| Project ID | NIH-10849923 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals of Hispanic descent who may have variations in blood coagulation factors.
✕Less likely to help
Patients who do not have any genetic predisposition to thrombotic diseases or those outside the Hispanic population may not benefit from this research.
What this research studies
This research investigates the genetic and epigenetic factors that regulate coagulation factor VIII (FVIII) and von Willebrand factor (VWF), which are crucial for blood clotting. By analyzing whole genome sequences from a diverse group of 14,000 Hispanic participants, the study aims to identify new genetic loci associated with FVIII and VWF levels. The research employs advanced methodologies, including Mendelian randomization, to explore how these factors contribute to thrombotic diseases. The goal is to fill knowledge gaps in the genetics of blood coagulation, particularly in underrepresented populations.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of thrombotic diseases, potentially reducing the risk of blood clots in patients.
How similar studies have gone: Previous research has successfully identified genetic determinants of blood coagulation factors, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Morrison, Alanna C — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Morrison, Alanna C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.