Understanding how genetics influence allergic reactions through a specific protein
Official title: Genetic Control of the SYK Tyrosine-protein Kinase in Allergy
Funded at Johns Hopkins University · NIH-11013905 · Data updated 2026-11-12
This study is looking at how a protein called SYK and our genes might play a role in allergies and asthma, with the hope of finding better, personalized treatments for people based on their unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 22, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $558,733 |
| NIH project number | 5R01AI181867-02 |
| Project ID | NIH-11013905 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with allergic diseases, particularly those with asthma or atopic conditions.
✕Less likely to help
Patients without allergic diseases or those who do not have a genetic predisposition to such conditions may not benefit from this research.
What this research studies
This research investigates the role of the SYK protein in allergic diseases, particularly how genetic variations affect its function and contribute to conditions like asthma. By examining the relationship between genetic markers and SYK expression in immune cells, the study aims to uncover the underlying mechanisms of allergic reactions. Patients may benefit from insights that could lead to more personalized and effective treatments for allergies and asthma based on their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to improved allergy treatments tailored to individual genetic profiles.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on allergic reactions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Gao, Li — Johns Hopkins University
- Study coordinator: Gao, Li
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.