Understanding how genetics and the environment affect cancer treatment with radiation
Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
This study is looking at how your genes and environment affect how well radiation therapy works with other cancer treatments, specifically for bladder and head and neck cancers, to help doctors find the best personalized treatment for you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10977552 on NIH RePORTER |
What this research studies
This research investigates how genomic factors and the surrounding environment influence the effectiveness of radiation therapy combined with other treatments for cancer. By focusing on bladder and head and neck cancers, the study aims to uncover the biological mechanisms that determine why some patients respond well to these therapies while others do not. Patients may be involved in trials that explore the use of antibody-drug conjugates and immune checkpoint inhibitors alongside radiation. The goal is to improve treatment outcomes by tailoring therapies based on individual genetic and immunological profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with bladder or head and neck cancers who are undergoing radiation therapy.
Not a fit: Patients with cancers not targeted by this research or those who are not receiving radiation therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments, improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in using combination therapies with radiation, indicating that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Chan, Timothy an-Thy — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Chan, Timothy an-Thy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.