Understanding how genetics and the environment affect cancer treatment with radiation
Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
This study is looking at what helps or hinders the success of radiation therapy when it's used with other treatments for bladder and head and neck cancers, so we can better understand why some patients do well and others don’t.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10896479 on NIH RePORTER |
What this research studies
This research investigates the factors that influence how effective radiation therapy is when combined with other treatments for cancer. It focuses on understanding the genetic and environmental elements that contribute to patients' responses to these therapies. By studying patients with bladder and head and neck cancers, the research aims to identify why some patients respond well to radiation combined with new drugs, while others do not. The approach includes innovative molecular characterization trials to uncover the underlying mechanisms of treatment efficacy and resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with bladder cancer or head and neck cancer who are undergoing radiation therapy.
Not a fit: Patients with cancers not included in the study, or those who are not receiving radiation therapy, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective radiation-based treatments for various cancers, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding the mechanisms of radiation therapy combined with systemic agents, indicating that this approach could yield significant insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Chan, Timothy an-Thy — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Chan, Timothy an-Thy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.