Understanding how genetics and small molecules affect Crohn's disease complications
Official title: Genetic and Small Molecule Regulation of Mechanisms of Crohn’s Disease Stricture Formation
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11078336 · Data updated 2026-11-12
This study is looking at how Crohn's Disease can cause problems like strictures that might need surgery, and it's for people with Crohn's who want to know more about how their condition works and what new treatments might help prevent these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $658,456 |
| NIH project number | 5R01DK135479-02 |
| Project ID | NIH-11078336 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Crohn's Disease, particularly those experiencing complications such as strictures.
✕Less likely to help
Patients with Crohn's Disease who do not have strictures or those who are not responsive to anti-TNF therapies may not benefit from this research.
What this research studies
This research investigates the mechanisms that lead to complications in Crohn's Disease, particularly focusing on the formation of strictures that often require surgical intervention. By examining interactions between different cell types in the intestines, the study aims to identify genetic factors and small molecules that could influence treatment responses. The researchers will utilize advanced techniques, including induced pluripotent stem cells and organoid co-culture systems, to explore how specific genetic variants affect inflammation and tissue repair. This approach may lead to new therapeutic strategies to prevent strictures in patients with Crohn's Disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce the need for surgery in Crohn's Disease patients by preventing stricture formation.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors influencing Crohn's Disease, but this specific approach utilizing iPSC technology is relatively novel.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Denson, Lee Armistead — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Denson, Lee Armistead
Related research
Other NIH-funded projects on the same topics.
-
Site-specific gene-microbial interactions in children with Crohn’s disease
A child-focused study explores how genes and gut microbes interact in very young children with Crohn’s disease to understand why the disease starts and how it might be treated.
-
Ultrasound markers to measure Crohn’s disease activity
A Mayo Clinic team is testing new 3D ultrasound methods to reliably track inflammation and scarring in Crohn’s disease using safe, affordable imaging that could replace more costly scans.
-
Understanding abnormal sugar building blocks in Crohn’s disease to guide smarter therapies
This project looks at how a specific genetic variation affects how Crohn’s disease works and whether targeting that pathway could lead to new treatments.
-
AI and single-cell tests to predict Crohn's disease course in children
This project uses artificial intelligence plus single-cell and other molecular data to predict which children and teens with Crohn's disease will have mild versus severe or treatment‑resistant disease.
-
How IL-23 Blockade in Crohn's Disease Changes Immune Cells
This study looks at how the IL-23 blocking therapy risankizumab affects immune cells in people with Crohn’s disease.
-
Metabolic signatures that predict outcomes in children with Crohn's
This project looks at metabolism patterns in children with Crohn's disease to help predict how their condition will progress and respond to treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.