Understanding how genetics and small molecules affect Crohn's disease complications
Genetic and Small Molecule Regulation of Mechanisms of Crohn’s Disease Stricture Formation
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11078336
This study is looking at how Crohn's Disease can cause problems like strictures that might need surgery, and it's for people with Crohn's who want to know more about how their condition works and what new treatments might help prevent these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11078336 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that lead to complications in Crohn's Disease, particularly focusing on the formation of strictures that often require surgical intervention. By examining interactions between different cell types in the intestines, the study aims to identify genetic factors and small molecules that could influence treatment responses. The researchers will utilize advanced techniques, including induced pluripotent stem cells and organoid co-culture systems, to explore how specific genetic variants affect inflammation and tissue repair. This approach may lead to new therapeutic strategies to prevent strictures in patients with Crohn's Disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's Disease, particularly those experiencing complications such as strictures.
Not a fit: Patients with Crohn's Disease who do not have strictures or those who are not responsive to anti-TNF therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce the need for surgery in Crohn's Disease patients by preventing stricture formation.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors influencing Crohn's Disease, but this specific approach utilizing iPSC technology is relatively novel.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENSON, LEE ARMISTEAD — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: DENSON, LEE ARMISTEAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.