Understanding how genetics and proteins affect Alzheimer's disease
Project 4: Cross-species Dissection of Cellular Response to APOE Genotype and AD Pathology Using Single-cell Multi-omics
This study is looking at how certain genes and proteins related to Alzheimer's disease work together, which could help us understand more about the disease and lead to better treatments for people affected by it.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10897932 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between genetic factors, specifically the APOE4 genotype, and key proteins involved in Alzheimer's disease, such as amyloid-beta and tau. By using advanced techniques like single-cell multi-omics, the study aims to dissect the cellular and molecular responses to these factors, which may lead to better understanding of how they contribute to cognitive decline and neural dysfunction. Patients may benefit from insights gained about the underlying mechanisms of Alzheimer's, potentially guiding future therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a genetic predisposition to Alzheimer's disease, particularly those carrying the APOE4 allele.
Not a fit: Patients without any genetic risk factors for Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease.
How similar studies have performed: Other research has shown promise in understanding Alzheimer's disease through genetic and protein interactions, indicating that this approach may yield valuable insights.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Corces, Michael Ryan — J. David Gladstone Institutes
- Study coordinator: Corces, Michael Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.