Understanding how genetics and immune responses affect severe fungal infections.
Host Immunogenetics and Fungal Virulence Mechanisms in Coccidioidomycosis
This study is looking at why some people get mild or serious infections from the Coccidioides fungus, and it aims to find out how our genes and immune system play a role, so we can better prevent and treat these infections for everyone affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11004658 on NIH RePORTER |
What this research studies
This research investigates the varying clinical outcomes of infections caused by the Coccidioides fungus, which can lead to conditions ranging from mild pulmonary disease to severe, life-threatening disseminated coccidioidomycosis. The team aims to uncover the genetic and immunological factors that contribute to these different outcomes, focusing on how the fungus exploits immune deficiencies. By combining expertise from immunology, genetics, and microbiology, the research seeks to improve prevention, diagnosis, and treatment strategies for those affected by this infection.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in endemic areas who have been diagnosed with coccidioidomycosis or are at risk of developing severe disease.
Not a fit: Patients who have already developed severe disseminated coccidioidomycosis may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictive tools and treatments for patients at risk of severe fungal infections.
How similar studies have performed: Previous research has shown promise in understanding immune responses to fungal infections, but this specific approach is novel and aims to fill critical gaps in knowledge.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Butte, Manish J — University of California Los Angeles
- Study coordinator: Butte, Manish J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.