Understanding how genetics and gut health affect weight loss and obesity.
The Contribution of Omic Profiles to Weight Loss and Obesity
This study is looking at how our genes, gut health, and body chemistry affect how well different weight loss methods work for people, and it’s for anyone interested in losing weight through either daily calorie cutting or intermittent fasting over a year.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11035152 on NIH RePORTER |
What this research studies
This research investigates the factors that influence how individuals respond to weight loss interventions, particularly focusing on genetics, gut microbiota, and metabolites. Participants will engage in a year-long lifestyle weight loss trial comparing daily caloric restriction to intermittent fasting. By analyzing biological samples and tracking changes in gut health and metabolic profiles, the study aims to uncover the underlying reasons for variability in weight loss success among individuals. The findings could lead to more personalized approaches to obesity treatment and prevention.
Who could benefit from this research
Good fit: Ideal candidates are adults over 21 years old who are overweight or obese and willing to participate in a weight loss intervention.
Not a fit: Patients who are not overweight or obese or those with contraindications to caloric restriction or fasting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide tailored weight loss strategies that improve outcomes for individuals struggling with obesity.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetics and gut microbiota in weight loss, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Stanislawski, Maggie a — University of Colorado Denver
- Study coordinator: Stanislawski, Maggie a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.