Understanding how genetics and environment interact to affect health
Determining the evolutionary forces shaping genotype-by-environment interactions
This study looks at how our genes change based on the environments we live in, helping us understand why some genetic traits and diseases are more common in certain groups of people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11083632 on NIH RePORTER |
What this research studies
This research investigates how evolutionary forces influence genetic variation in humans, particularly focusing on how different environments can affect gene expression and contribute to genetic diseases. By analyzing large datasets that include genomic, transcriptomic, and phenotypic information, the researchers aim to uncover the mechanisms behind genotype-by-environment interactions. This could help identify why certain genetic traits are more prevalent in specific populations and how they respond to environmental changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known genetic conditions or those from diverse populations that may exhibit varying responses to environmental factors.
Not a fit: Patients with purely environmental health issues unrelated to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of genetic diseases by identifying how environmental factors influence genetic traits.
How similar studies have performed: Previous research has shown that understanding genotype-by-environment interactions can significantly enhance our knowledge of genetic diseases, indicating that this approach has potential for success.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Josephs, Emily — Michigan State University
- Study coordinator: Josephs, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.