Understanding how genetics and environment influence substance use in adolescents
A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers
This study is looking at how both our genes and our surroundings affect how teens aged 12 to 20 use substances like alcohol and cigarettes, by gathering and analyzing data from young people around the world.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10645089 on NIH RePORTER |
What this research studies
This research investigates how both genetic factors and environmental influences contribute to substance use behaviors, such as smoking and drinking, among adolescents aged 12 to 20. By utilizing a decentralized data analysis platform, the study aims to analyze extensive imaging and genetic data from thousands of participants across various countries, including the U.S., Europe, China, and India. The research will explore how factors like cultural acceptance, urbanization, and climate impact these behaviors and their associated brain biomarkers. This approach allows for a comprehensive understanding of the interplay between genetics and environment without compromising data privacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12 to 20 who may be experiencing or at risk for substance use behaviors.
Not a fit: Patients outside the age range of 12 to 20 or those not engaged in substance use behaviors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and intervention strategies for substance use in adolescents.
How similar studies have performed: Previous research has shown promise in understanding the genetic and environmental interactions in substance use, but this specific decentralized approach is relatively novel.
Where this research is happening
Atlanta, United States
- Georgia State University — Atlanta, United States (Active)
Researchers
- Principal investigator: Calhoun, Vince D — Georgia State University
- Study coordinator: Calhoun, Vince D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.