Understanding how genetics and environment affect mammographic density and breast cancer risk
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
This study is looking at how your genes and the environment around you can affect mammographic density, which is important for understanding breast cancer risk, and it aims to help women learn more about their own risk based on these factors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10773173 on NIH RePORTER |
What this research studies
This research investigates the relationship between genetic factors, gene expression, and environmental influences on mammographic density, which is linked to breast cancer risk. By analyzing data from a large group of women, the study aims to identify specific genetic variants and environmental interactions that contribute to variations in mammographic density. The approach includes genome-wide association studies and transcriptome-wide association studies to uncover new insights into how these factors work together. Patients may benefit from a better understanding of their breast cancer risk based on their genetic and environmental profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of European ancestry who are interested in understanding their breast cancer risk factors.
Not a fit: Patients who do not identify as women or those outside the specified ancestry may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and personalized prevention strategies for breast cancer.
How similar studies have performed: Previous research has shown success in identifying genetic risk factors for breast cancer, making this approach promising for further advancements.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Lindstroem, Sara — University of Washington
- Study coordinator: Lindstroem, Sara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.