Understanding how genetics and environment affect cognitive resilience in older adults
Genetic and Environmental Drivers of Cognitive Resilience in Aging Populations
This study is looking at what helps some older adults stay sharp and think clearly even when facing Alzheimer's or similar conditions, and it's for people who want to contribute to finding new ways to keep our brains healthy as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11173930 on NIH RePORTER |
What this research studies
This research investigates the factors that contribute to cognitive resilience in aging populations, particularly in the context of Alzheimer's disease and related dementias. By focusing on both genetic and environmental influences, the study aims to identify biomarkers and pathways that help some individuals maintain cognitive function despite aging or brain pathology. Utilizing a multi-omics approach, researchers will analyze existing genomic data, plasma proteins, and neuroimaging to uncover insights that could lead to new prevention strategies. Participants may undergo assessments and provide biological samples to help advance this important work.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are cognitively healthy or at risk for Alzheimer's disease and related dementias.
Not a fit: Patients with advanced Alzheimer's disease or severe cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying cognitive decline in older adults.
How similar studies have performed: Previous research has shown promise in understanding cognitive resilience, but this multi-omics approach is relatively novel and untested.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Thomas, Alvin G. — Washington University
- Study coordinator: Thomas, Alvin G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.