Understanding how genetics and environment affect blood cell development
Official title: Deciphering genotype-environmental interaction that drives HSPC dysfunction
Funded at Albert Einstein College of Medicine · NIH-10996565 · Data updated 2026-11-12
This study is looking at how certain gene changes and environmental factors affect blood cell production, especially in people with myelodysplastic syndromes (MDS), to help us understand blood cancers better and find new ways to treat them.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | September 16, 2024 |
| Project end | September 15, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL172393-01A1 |
| Project ID | NIH-10996565 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic predispositions to myeloid malignancies, particularly those with DDX41 mutations.
✕Less likely to help
Patients without genetic mutations related to HSPC dysfunction or those with unrelated blood disorders may not benefit from this research.
What this research studies
This research investigates how genetic mutations and environmental factors influence the function of hematopoietic stem and progenitor cells (HSPCs), which are crucial for producing blood cells. By studying both human and zebrafish models, the research aims to uncover the mechanisms behind myeloid malignancies, particularly myelodysplastic syndromes (MDS). The approach includes examining the effects of specific gene mutations, such as DDX41, and how they interact with aging and environmental changes to drive HSPC dysfunction. This could lead to insights into the progression of blood cancers and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with blood cancers like MDS.
How similar studies have gone: Previous research has shown success in understanding genetic and environmental interactions in blood cell development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Feliz Norberto, Maria — Albert Einstein College of Medicine
- Study coordinator: Feliz Norberto, Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.