Understanding how genetics and drug interactions affect individual responses to medications
Genomic and drug-drug interaction mechanisms of interindividual variability in drug disposition
This study is looking at how our genes and the way different medications work together can affect how well drugs work for each person, with the goal of creating safer and more effective treatments just for you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11075228 on NIH RePORTER |
What this research studies
This research investigates the reasons behind the differences in how individuals respond to medications, focusing on genetic factors and interactions between drugs. By examining these variables, the study aims to develop personalized drug therapies that enhance safety and effectiveness. The research employs advanced techniques, including genomic biomarkers and clinical phenotyping tools, to identify how inherited traits and drug combinations influence drug metabolism. Ultimately, the goal is to improve drug dosing guidelines and minimize adverse effects for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are taking multiple medications or have experienced adverse drug reactions.
Not a fit: Patients who are not currently on any medications or those with stable drug regimens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective medication regimens, reducing the risk of adverse drug reactions.
How similar studies have performed: Previous research has shown success in understanding drug interactions and genetic variability, indicating that this approach has the potential for significant advancements.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Desta, Zeruesenay — Indiana University Indianapolis
- Study coordinator: Desta, Zeruesenay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.