Understanding how genetics and childhood experiences affect mental health disorders
Official title: Individually Measured Endophenotypes to Advance Computational Translation in Mental Health
Funded at Arizona State University-Tempe Campus · NIH-10909679 · Data updated 2026-11-12
This study is looking at how our genes, brain, and past experiences with stress can affect mental health issues in teens and adults, and it aims to find better ways to diagnose and treat these conditions by understanding them in a more detailed way.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | September 10, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,413,000 |
| NIH project number | 1DP2MH140150-01 |
| Project ID | NIH-10909679 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adolescents and adults who have experienced trauma and are struggling with stress-related psychiatric disorders.
✕Less likely to help
Patients who do not have a history of trauma or who are not affected by stress-related psychiatric disorders may not benefit from this research.
What this research studies
This research investigates the biological and environmental factors contributing to stress-related psychiatric disorders (SRPDs) in adolescents and adults. It aims to develop a new model that combines genetic, epigenetic, and neurobiological data with individual histories of adverse childhood experiences to identify unique biocomposite clusters of SRPDs. By treating symptoms and biomarkers as continuous variables rather than binary, the research seeks to improve diagnosis and treatment approaches for these complex disorders. Participants may undergo assessments that evaluate their genetic makeup, brain structure, and personal trauma history.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for individuals suffering from stress-related psychiatric disorders.
How similar studies have gone: Previous research has shown promise in using genetic and environmental factors to understand mental health disorders, making this approach both innovative and grounded in existing findings.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Lewis, Candace Renee — Arizona State University-Tempe Campus
- Study coordinator: Lewis, Candace Renee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.