Understanding how genetics and ancestry affect colorectal cancer outcomes
Elucidating the role of transcriptomics in driving ethnicity and ancestry-related disparities in colorectal cancer
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-11064035
This study is looking at why people from different ethnic backgrounds have different experiences with colorectal cancer, especially how genes and the immune system affect treatment responses, so we can find better ways to help everyone, particularly African American patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11064035 on ClinicalTrials.gov |
What this research studies
This research investigates the disparities in colorectal cancer outcomes among different ethnic groups, focusing on how genetic factors and RNA splicing contribute to these differences. By analyzing tumor samples and patient data, the study aims to identify unique molecular targets that could lead to more effective precision medicine interventions. The research also explores the role of the immune system in response to treatments like immunotherapy, particularly in African American patients who may respond differently than others. Overall, the goal is to enhance treatment options and improve outcomes for underrepresented populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include colorectal cancer patients from minority ethnic groups, particularly African Americans.
Not a fit: Patients with colorectal cancer who do not belong to minority ethnic groups may not directly benefit from the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for colorectal cancer patients from diverse backgrounds.
How similar studies have performed: Previous research has shown promising results in understanding cancer disparities through genetic and immunological approaches, indicating that this study builds on established findings.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FIGUEIREDO, JANE C. — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: FIGUEIREDO, JANE C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.