Understanding how genetics affects telomere length and aging
Genetic and epigenetic architecture of natural telomere length variation
['FUNDING_R01'] · MARSHALL UNIVERSITY · NIH-11043312
This study looks at how certain genes affect the length of telomeres, which are important for how long our cells live and how we age, using a small plant called Arabidopsis thaliana, and the findings could help us understand aging and related health issues in people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MARSHALL UNIVERSITY (nih funded) |
| Locations | 1 site (Huntington, UNITED STATES) |
| Trial ID | NIH-11043312 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and epigenetic factors that influence telomere length, which is crucial for cellular lifespan and aging. By studying the model plant Arabidopsis thaliana, researchers aim to identify specific genes and mechanisms that regulate telomere length and their implications for age-related diseases. The study employs a combination of genetic, genomic, and biochemical techniques to uncover how variations in telomere length can affect health outcomes. Insights gained from this research could lead to a better understanding of aging and related disorders in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the genetic factors influencing aging and those with age-related disorders.
Not a fit: Patients with no interest in genetic research or those not affected by age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into the biological mechanisms of aging and potentially lead to new strategies for preventing age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding telomere biology, but this specific approach using Arabidopsis is relatively novel.
Where this research is happening
Huntington, UNITED STATES
- MARSHALL UNIVERSITY — Huntington, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAKIROV, EUGENE V — MARSHALL UNIVERSITY
- Study coordinator: SHAKIROV, EUGENE V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease, age dependent disorder, age related human disease