Understanding how genetics affects heart regeneration
Genetic interactions and multifactorial genetics mediate myocardial regeneration
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11023048
This study is looking at how certain genes help the heart heal after an injury, like a heart attack, and it's for anyone interested in understanding why some people recover better than others.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11023048 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that influence the heart's ability to regenerate after injury, such as a heart attack. It focuses on a specific type of heart cell, called mononuclear diploid cardiomyocytes, which have the potential to divide and repair heart tissue. By identifying and studying various genes that affect these cells, the research aims to uncover how some individuals can recover better than others after cardiac damage. The approach includes using genetic analysis to find candidate genes that may enhance heart regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced a myocardial infarction or other forms of cardiac injury.
Not a fit: Patients with non-cardiac conditions or those who have not experienced heart injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart healing and recovery for patients with heart injuries.
How similar studies have performed: Other research has shown promising results in understanding genetic influences on heart regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PATTERSON, MICHAELA — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: PATTERSON, MICHAELA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene