Understanding how genetics affects B cell function in type 1 diabetes
Genetic contribution to loss of B cell anergy during development of type 1 diabetes
This study is looking at how certain genes might affect the immune system's B cells in people who have a family member with type 1 diabetes, to help us understand why some people might develop the condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10885986 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to the loss of B cell anergy, which is a state of immune tolerance, in individuals at risk for type 1 diabetes. The study focuses on the PTPN2 risk allele and its impact on B cell behavior in first-degree relatives of type 1 diabetes patients. By examining how these genetic variations affect B cell responses, the research aims to uncover mechanisms that could lead to the development of type 1 diabetes. The approach includes both human studies and mouse models to validate findings and understand the underlying biology.
Who could benefit from this research
Good fit: Ideal candidates for this research include first-degree relatives of individuals with type 1 diabetes, particularly those who are autoantibody positive.
Not a fit: Patients who do not have a family history of type 1 diabetes or are not at risk for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying the onset of type 1 diabetes in at-risk individuals.
How similar studies have performed: Previous studies in animal models have shown promising results regarding the role of genetic factors in B cell function, but this research aims to translate those findings to human subjects.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Smith, Mia — University of Colorado Denver
- Study coordinator: Smith, Mia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.