Understanding how genetics affects arsenic metabolism
Biological mechanisms underlying inherited genetic effects on arsenic metabolism
['FUNDING_R21'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10727165
This study is looking at how our genes affect how our bodies handle arsenic, a harmful substance often found in dirty water, to help identify who might be at greater risk and find ways to keep people safer from its effects.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10727165 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic factors influence the body's ability to metabolize inorganic arsenic, a toxic substance found in contaminated water. By identifying specific genetic variations that affect arsenic metabolism, the study aims to classify individuals based on their risk of toxicity and to understand the biological mechanisms behind these differences. The researchers will use innovative gene-editing techniques to explore how certain genetic markers impact arsenic processing in human cells. This could lead to better strategies for reducing health risks associated with arsenic exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who consume water contaminated with inorganic arsenic and have a family history of related health issues.
Not a fit: Patients who do not consume arsenic-contaminated water or who do not have genetic variations affecting arsenic metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized interventions that help reduce the health risks of arsenic exposure for individuals with specific genetic profiles.
How similar studies have performed: Previous studies have identified genetic variants linked to arsenic metabolism, but this research aims to explore the underlying biological mechanisms, making it a novel approach.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VANDER GRIEND, DONALD JAMES — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: VANDER GRIEND, DONALD JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Cardiovascular Diseases, cardiovascular disorder