Understanding how genetics affects arsenic metabolism
Official title: Biological mechanisms underlying inherited genetic effects on arsenic metabolism
Funded at University of Illinois at Chicago · NIH-10727165 · Data updated 2026-11-12
This study is looking at how our genes affect how our bodies handle arsenic, a harmful substance often found in dirty water, to help identify who might be at greater risk and find ways to keep people safer from its effects.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | August 2, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $457,411 |
| NIH project number | 1R21ES035491-01 |
| Project ID | NIH-10727165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who consume water contaminated with inorganic arsenic and have a family history of related health issues.
✕Less likely to help
Patients who do not consume arsenic-contaminated water or who do not have genetic variations affecting arsenic metabolism may not benefit from this research.
What this research studies
This research investigates how genetic factors influence the body's ability to metabolize inorganic arsenic, a toxic substance found in contaminated water. By identifying specific genetic variations that affect arsenic metabolism, the study aims to classify individuals based on their risk of toxicity and to understand the biological mechanisms behind these differences. The researchers will use innovative gene-editing techniques to explore how certain genetic markers impact arsenic processing in human cells. This could lead to better strategies for reducing health risks associated with arsenic exposure.
Why it matters
Potential benefit: If successful, this research could lead to personalized interventions that help reduce the health risks of arsenic exposure for individuals with specific genetic profiles.
How similar studies have gone: Previous studies have identified genetic variants linked to arsenic metabolism, but this research aims to explore the underlying biological mechanisms, making it a novel approach.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Vander Griend, Donald James — University of Illinois at Chicago
- Study coordinator: Vander Griend, Donald James
Related research
Other NIH-funded projects on the same topics.
-
MSC Secretome Eye Drops to Speed Healing of Corneal Wounds
A new eye drop made from stem cell–secreted factors is being tested to help adults with non-healing corneal wounds recover vision faster.
-
UIC Center for Healthy Work
A national program led by UIC aims to improve the health and well-being of workers through collaborative research and practical solutions.
-
Coordinated Oral Health Promotion for Chicago Kids
A long-running study in Chicago is following children and their caregivers to find ways to reduce tooth decay and improve daily life for families.
-
Targeting p38 MAPK to slow ALS-related axonal damage
Aims to block a specific brain-wide signaling pathway (p38 MAPK) to reduce nerve damage in people with various genetic forms of ALS.
-
Precision nanomedicine to calm inflammation and protect bone in gum disease
A new, targeted nanomedicine approach aims to reduce gum inflammation and prevent bone loss in adults with periodontal disease.
-
Role of DPP in Dental Pulp Stem Cells and their Regenerative Potential
A project explores how a natural tooth protein helps dental pulp stem cells repair and regenerate the tooth’s inner tissue.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.