Understanding how genetics affect Von Willebrand Factor levels in health and disease
Official title: Genomic regulation of VWF levels in health and disease
Funded at Washington University · NIH-11016811 · Data updated 2026-11-12
This study is looking at how our genes affect the levels of a protein called Von Willebrand Factor, which is important for blood clotting, especially in people with low levels of it, to help us understand why some people might bleed more easily or have heart issues, and it focuses on individuals of African ancestry.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 15, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $337,604 |
| NIH project number | 1P01HL173579-01A1 |
| Project ID | NIH-11016811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with low Von Willebrand Factor levels, particularly those of African ancestry or those experiencing unexplained bleeding issues.
✕Less likely to help
Patients who do not have low VWF levels or those without a genetic predisposition to bleeding disorders may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence Von Willebrand Factor (VWF) levels, which are important for blood clotting and can affect the risk of bleeding and cardiovascular diseases. By analyzing genetic data from diverse populations, particularly those of African ancestry, the study aims to identify both common and rare genetic variants that contribute to variations in VWF levels. Participants with low VWF levels will undergo advanced whole genome sequencing to uncover the underlying biological mechanisms and improve our understanding of how aging and genetic diversity impact VWF levels.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and targeted treatments for individuals with bleeding disorders and cardiovascular disease.
How similar studies have gone: Previous genetic studies have successfully identified loci associated with VWF levels, but this research aims to delve deeper into the genetic mechanisms, making it a novel approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Di Paola, Jorge a — Washington University
- Study coordinator: Di Paola, Jorge a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.