Understanding how genetics affect the body's response to Aspergillus infections
Genetic Determinants of Aspergillus host-pathogen interactions
This study is looking at how our genes affect how well our bodies fight off Aspergillus, a common fungus that can make people with weakened immune systems, like those with asthma or cystic fibrosis, very sick, with the goal of finding new ways to help these patients stay healthier.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10873894 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence how the body interacts with Aspergillus, a common airborne fungus that can cause serious infections, especially in individuals with weakened immune systems. The team aims to identify specific genetic pathways that could be targeted to improve the immune response against these infections. By studying how the body recognizes and responds to Aspergillus, the researchers hope to develop new therapeutic strategies that could enhance patient outcomes. This work is particularly relevant for patients suffering from conditions like asthma or cystic fibrosis, where Aspergillus can worsen their health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with compromised immune systems or chronic respiratory conditions, such as asthma or cystic fibrosis.
Not a fit: Patients who are healthy and do not have any underlying respiratory conditions or immune deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from Aspergillus infections, potentially reducing morbidity and mortality rates.
How similar studies have performed: Previous research has shown promise in understanding host-pathogen interactions with other pathogens, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Fortwendel, Jarrod R. — University of Tennessee Health Sci Ctr
- Study coordinator: Fortwendel, Jarrod R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.