Understanding how genetics affect susceptibility to SARS-CoV-2
Host genetic determinants regulating susceptibility/resistance to SARS-CoV-2
This study is looking at how our genes might affect how we respond to COVID-19, using mice to understand why some people get really sick while others don’t, with the hope of finding ways to help those at higher risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10625449 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence how individuals respond to SARS-CoV-2, the virus responsible for COVID-19. By studying specific strains of mice that exhibit different levels of susceptibility to the virus, researchers aim to uncover the biological mechanisms that lead to varying clinical outcomes in humans. The approach involves using systems genetics to analyze the differences in host responses to the virus, which could provide insights into why some people experience severe symptoms while others remain asymptomatic. The findings could ultimately help identify individuals at higher risk and inform targeted prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a known predisposition to severe COVID-19 or those who have experienced significant symptoms upon infection.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those with no history of COVID-19 symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and identification of individuals at risk for severe COVID-19, enabling more effective prevention and treatment strategies.
How similar studies have performed: Previous research has shown success in using genetic models to understand viral infections, suggesting that this approach could yield valuable insights into COVID-19 susceptibility.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Li, Kui — University of Tennessee Health Sci Ctr
- Study coordinator: Li, Kui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.