Understanding how genetics affect side effects of HIV treatments
Pharmacogenomics and Systems Pharmacology Approaches to Toxicity, Tolerability, and Comorbidities Associated with Modern Antiretroviral Therapies
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10668985
This study is looking at how your genes might affect how well you respond to HIV treatment and the side effects you experience, so that doctors can create more personalized and effective treatment plans just for you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10668985 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic differences among individuals living with HIV can influence their responses to antiretroviral therapy (ART), particularly regarding side effects and comorbidities. By analyzing a large cohort of patients, the study aims to identify genetic markers that predict adverse reactions to specific ART combinations. This could lead to more personalized treatment plans that enhance drug efficacy and minimize harmful side effects. The research utilizes extensive clinical data and genetic information to explore these relationships.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are undergoing antiretroviral therapy and may experience side effects or comorbidities.
Not a fit: Patients who are not currently on antiretroviral therapy or those without genetic variations that affect drug metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more tailored HIV treatments that reduce side effects and improve overall health outcomes for patients.
How similar studies have performed: Previous research has shown promising results in using pharmacogenomics to tailor treatments for various conditions, indicating potential success for this approach in HIV treatment.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PETER, INGA — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: PETER, INGA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.