Understanding how genetics affect radiation response in cancer treatment
Germline Genetic Modifiers of Radiation Response
This study is looking at how your genes might affect how well you respond to radiation therapy if you have breast cancer, with the hope of finding ways to adjust treatment to keep you safer and healthier.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sri International NIH-funded |
| Lab location | 1 site (Menlo Park, United States) |
| Project ID | NIH-10741022 on NIH RePORTER |
What this research studies
This research investigates how genetic differences among patients influence their response to radiation therapy, particularly in those with breast cancer. By analyzing genetic variants and their association with radiation sensitivity, the study aims to identify patients who may be at higher risk for radiation-induced injuries. Using advanced techniques like genomics and cell culture, researchers will expose normal tissue cells from cancer patients to radiation to observe their responses. The goal is to develop predictive tools that can help tailor radiation doses to minimize harm and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients who are undergoing radiation therapy and have diverse genetic backgrounds.
Not a fit: Patients who are not receiving radiation therapy or those with cancers other than breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized radiation therapy that reduces the risk of harmful side effects for cancer patients.
How similar studies have performed: Previous research has shown promise in using genetic profiling to predict patient responses to various treatments, indicating that this approach may yield valuable insights.
Where this research is happening
Menlo Park, United States
- Sri International — Menlo Park, United States (Active)
Researchers
- Principal investigator: Mcdonald, John Tyson — Sri International
- Study coordinator: Mcdonald, John Tyson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.