Understanding how genetics affect outcomes in diverticulitis
Genetic Determinants of Outcomes in Diverticular Disease
This study is looking at how your genes might affect how serious your diverticulitis gets, helping doctors figure out who might need more care or treatment based on their genetic makeup and lifestyle.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10791938 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence the severity of diverticulitis, a common colorectal disease that causes abdominal pain and gastrointestinal distress. By analyzing genetic data, the study aims to identify which patients are at higher risk for severe complications, such as multiple hospitalizations or the need for surgery. The approach includes examining genetic loci associated with diverticulitis and how these interact with lifestyle factors like body fat. This could lead to better risk stratification and personalized treatment plans for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of diverticulitis, particularly those who have experienced severe episodes or complications.
Not a fit: Patients who have never been diagnosed with diverticulitis or those with other unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prediction and management of diverticulitis, potentially reducing severe complications and hospitalizations.
How similar studies have performed: Previous research has shown promising results in understanding genetic contributions to various diseases, suggesting that this approach could yield valuable insights for diverticulitis as well.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Maguire, Lillias Holmes — University of Pennsylvania
- Study coordinator: Maguire, Lillias Holmes
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.