Understanding how genetics affect immune responses to infections
Official title: iPSC-derived macrophages as a model to study the genetic basis of inter-individual variation in immune responses to pathogens
Funded at University of Chicago · NIH-11047267 · Data updated 2026-11-12
This study is looking at how our unique genes affect how our immune system fights off infections like tuberculosis and the flu, using special cells to help find out which genes play a role, so that one day, treatments can be tailored just for you based on your genetic background.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 24, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $785,511 |
| NIH project number | 1R01AI182148-01A1 |
| Project ID | NIH-11047267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with varying responses to infections, particularly those with a history of tuberculosis or influenza.
✕Less likely to help
Patients who do not have a history of infectious diseases or genetic predispositions to immune response variations may not benefit from this research.
What this research studies
This research investigates how genetic differences among individuals influence their immune responses to infectious diseases like tuberculosis and influenza. By using induced pluripotent stem cells (iPSCs) to create macrophages, the study aims to identify specific genes and regulatory pathways that contribute to variations in immune responses. The approach combines advanced techniques in genomics and immunology to explore both genetic and epigenetic factors affecting susceptibility to infections. Patients may benefit from insights that could lead to personalized treatments based on their genetic makeup.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for infectious diseases based on individual genetic profiles.
How similar studies have gone: Previous research has shown success in using genetic approaches to understand immune responses, indicating that this study builds on established methodologies.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Barreiro, Luis Bruno — University of Chicago
- Study coordinator: Barreiro, Luis Bruno
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.