Understanding how genetics affect dosing of a medication for children with movement disorders.
Official title: Pharmacogenomic Contribution to the Biotransformation of Trihexyphenidyl and Development of a Precision Dosing Model for Children with Dystonia and Cerebral Palsy
Funded at Children's Mercy Hosp (Kansas City, Mo) · NIH-11052990 · Data updated 2026-11-12
This study is looking at how kids with cerebral palsy process the medication Trihexyphenidyl differently based on their genes, so we can find the best dose for each child and make their treatment safer and more effective.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | January 20, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $164,160 |
| NIH project number | 1K23HD114899-01A1 |
| Project ID | NIH-11052990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with dystonia associated with cerebral palsy.
✕Less likely to help
Patients who do not have dystonia or cerebral palsy may not benefit from this research.
What this research studies
This research focuses on developing a precision dosing model for Trihexyphenidyl, a medication used to treat dystonia in children with cerebral palsy. The study aims to understand how genetic differences among children can influence how they metabolize this medication, which could lead to more effective and safer treatment options. By investigating pharmacogenomic factors, the research seeks to minimize side effects and improve therapeutic outcomes for young patients. The ultimate goal is to establish a standardized dosing approach that can be used in clinical trials and everyday practice.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children suffering from dystonia and cerebral palsy.
How similar studies have gone: Previous research has shown promise in using pharmacogenomic approaches to optimize medication dosing, indicating potential for success in this novel application.
Where this research is happening
-
Children's Mercy Hosp (Kansas City, Mo)
Kansas City, United States Active
Researchers
- Principal investigator: Gelineau-Morel, Rose Nicole — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Gelineau-Morel, Rose Nicole
Related research
Other NIH-funded projects on the same topics.
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Caregiver-reported Dystonia Impact in Cerebral Palsy (CARDI-CP)
A caregiver-facing project to create an easy, reliable way for families to describe how dystonia affects children and adults with cerebral palsy.
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Measuring how kids with cerebral palsy adapt their walking
A study to understand how children with cerebral palsy learn and adjust walking, and how personalized feedback during walking might improve their mobility.
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Role of THAP1 in brain cell support cells shaping brain development
Aims to understand how the THAP1 protein in oligodendrocyte lineage cells helps shape the brain’s environment and myelination during development, which may relate to a movement disorder called DYT6 dystonia.
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Precise measure of how CP affects movement to guide treatment
Aims to create precise, child-friendly ways to measure selective motor control in cerebral palsy so treatment can be tailored to each child.
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Non-invasive spinal stimulation to help kids with cerebral palsy move and reduce stiffness
This study tests a non-invasive spinal stimulation plus treadmill training to reduce spasticity and improve walking in children with cerebral palsy.
-
Leukocyte RNA biomarkers to help diagnose and monitor dystonia
A small study will look for RNA signatures in blood that could help diagnose and track dystonia in people who have the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.