Understanding how genetics affect diabetes treatment response
Pharmacogenetic discovery in the GRADE comparative effectiveness type 2 diabetes clinical trial
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10814158
This study is looking at how your genes might affect how well different diabetes medications work for you, so that doctors can personalize your treatment for better blood sugar control.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10814158 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic differences among individuals with type 2 diabetes can influence their response to various glucose-lowering medications. By analyzing genetic data from participants in the GRADE study, the researchers aim to identify specific genomic regions that correlate with treatment efficacy and side effects. This approach includes examining how genetics may affect insulin sensitivity and other key traits related to glucose control. The goal is to tailor diabetes treatment based on individual genetic profiles, potentially leading to more effective management of the condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes who are currently being treated with glucose-lowering medications.
Not a fit: Patients who do not have type 2 diabetes or those who are not currently on glucose-lowering medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized diabetes treatments that are more effective for individual patients based on their genetic makeup.
How similar studies have performed: Previous research has shown promising results in using genetic information to guide treatment decisions in diabetes, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FLOREZ, JOSE CARLOS — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: FLOREZ, JOSE CARLOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: diabetes, Diabetes Mellitus, Adult-Onset Diabetes Mellitus, Ketosis-Resistant Diabetes Mellitus