Understanding how genetics affect cannabis use and its consequences
Official title: Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans
Funded at Yale University · NIH-10932912 · Data updated 2026-11-12
This study is looking at how your genes might affect your chances of developing problems with cannabis use and how you respond to it, so if you're someone who uses cannabis and is curious about its effects on your mental health, you could help by sharing your experiences and participating in some genetic testing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 30, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $564,257 |
| NIH project number | 5R01DA058862-02 |
| Project ID | NIH-10932912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of cannabis use, particularly those experiencing cognitive or psychological issues.
✕Less likely to help
Patients who do not use cannabis or have no history of related cognitive or psychological issues may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence an individual's risk of developing cannabis use disorder and their response to cannabinoids. By analyzing genetic data, the study aims to clarify how these factors contribute to addiction, psychosis, and cognitive impairment associated with cannabis use. The research combines expertise from genetics and cannabinoid pharmacology to explore the relationship between cannabis exposure and mental health outcomes. Patients may be asked to participate in genetic testing and provide information about their cannabis use and mental health history.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals at risk of cannabis-related disorders.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of substance use disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: D'souza, Deepak Cyril — Yale University
- Study coordinator: D'souza, Deepak Cyril
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.