Understanding how genetics affect cancer treatment responses
Towards Precision Immuno-Oncology: Unraveling the Genomic Determinants and Mechanisms Underlying Immunotherapy Efficacy and Resistance
This study is looking at how your genes might affect how well you respond to certain cancer treatments, helping doctors find better, personalized options for you based on your unique genetic makeup.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10917198 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence how well cancer patients respond to immunotherapy, specifically treatments targeting CTLA4 and PD-1. By analyzing the genetic makeup of tumors and patients, the study aims to identify why some patients benefit from these therapies while others do not. The researchers will explore the role of mutations and DNA repair mechanisms in shaping the immune response to cancer treatments. Ultimately, the goal is to develop personalized treatment strategies that improve outcomes for cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients undergoing immunotherapy who may have varying responses based on their genetic profiles.
Not a fit: Patients who are not receiving immunotherapy or those with non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored immunotherapy treatments for cancer patients.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on immunotherapy responses, indicating that this approach has potential for significant advancements.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Chan, Timothy an-Thy — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Chan, Timothy an-Thy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.