Understanding how genetics affect blood clotting and bleeding disorders
Official title: The Molecular Genetics of Hemostasis
Funded at University of Michigan at Ann Arbor · NIH-11036279 · Data updated 2026-11-12
This study is looking at how our genes affect blood clotting and bleeding disorders, like TTP and hemolytic uremic syndrome, to help find better treatments for people who have these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2031 |
| Funding year | 2025 |
| Award (this year) | $846,995 |
| NIH project number | 5R35HL171421-02 |
| Project ID | NIH-11036279 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with genetic bleeding disorders such as hemophilia or TTP.
✕Less likely to help
Patients without any genetic bleeding disorders or those not affected by hemostasis-related conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors that regulate blood clotting and bleeding disorders by studying human patients with related genetic conditions. It focuses on understanding the diversity of endothelial cells in blood vessels and their role in diseases like thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome. The research employs advanced techniques to analyze proteins involved in hemostasis and aims to develop new therapeutic approaches. By identifying genetic modifiers and characterizing gene expression, the study seeks to enhance precision medicine for patients with bleeding disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with bleeding disorders.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in bleeding disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Ginsburg, David — University of Michigan at Ann Arbor
- Study coordinator: Ginsburg, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.