Understanding how genetics affect blood clotting and bleeding disorders
The Molecular Genetics of Hemostasis
This study is looking at how our genes affect blood clotting and bleeding disorders, like TTP and hemolytic uremic syndrome, to help find better treatments for people who have these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11036279 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that regulate blood clotting and bleeding disorders by studying human patients with related genetic conditions. It focuses on understanding the diversity of endothelial cells in blood vessels and their role in diseases like thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome. The research employs advanced techniques to analyze proteins involved in hemostasis and aims to develop new therapeutic approaches. By identifying genetic modifiers and characterizing gene expression, the study seeks to enhance precision medicine for patients with bleeding disorders.
Who could benefit from this research
Good fit: Ideal candidates include individuals with genetic bleeding disorders such as hemophilia or TTP.
Not a fit: Patients without any genetic bleeding disorders or those not affected by hemostasis-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with bleeding disorders.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in bleeding disorders, indicating that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Ginsburg, David — University of Michigan at Ann Arbor
- Study coordinator: Ginsburg, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.