Understanding how genetics affect allergic reactions to honeybee venom
Characterization of innate and IgE-mediated mast cell functions in honeybee venom allergy using Collaborative Cross mice
This study is looking at how our genes affect how mast cells react to honeybee venom, especially in people with allergies, to help find better ways to treat severe allergic reactions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10898758 on NIH RePORTER |
What this research studies
This research investigates how genetic traits influence the way mast cells respond to honeybee venom, particularly in individuals with IgE-mediated allergies. Using a special breed of mice known as Collaborative Cross mice, the study aims to explore the mechanisms behind mast cell activation and the subsequent allergic reactions. By examining the release of various mediators from mast cells, the research seeks to uncover the biological processes that lead to symptoms of allergic diseases and anaphylaxis. The findings could provide insights into potential therapeutic approaches for managing severe allergic reactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have a known allergy to honeybee venom and experience IgE-mediated allergic reactions.
Not a fit: Patients who do not have a history of honeybee venom allergy or those with other types of allergies unrelated to mast cell activation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for individuals suffering from honeybee venom allergies.
How similar studies have performed: Previous research has shown that similar approaches using animal models have successfully identified mechanisms of allergic responses, suggesting potential for meaningful advancements in this area.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Galli, Stephen Joseph — Stanford University
- Study coordinator: Galli, Stephen Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.