Understanding how genetics affect adrenal suppression from inhaled corticosteroids in asthma patients
Pharmacogenomics of Adrenal Suppression with Inhaled Corticosteroids (PhASIC)
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10842248
This study is looking at how your genes might affect how well inhaled corticosteroids work for your asthma and whether they could cause side effects, helping doctors find safer treatment options just for you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10842248 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic factors influence the effectiveness and side effects of inhaled corticosteroids used to treat asthma. By analyzing the genetic makeup of asthma patients, the study aims to identify molecular predictors that can help clinicians determine which patients are at risk for adrenal suppression, a serious side effect of long-term corticosteroid use. The approach combines systems biology with pharmacogenomics to better understand individual responses to treatment, potentially leading to more personalized and safer asthma management strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are asthma patients who are currently using inhaled corticosteroids and may be experiencing poor responsiveness to treatment.
Not a fit: Patients who do not have asthma or are not using inhaled corticosteroids are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment plans for asthma patients, reducing the risk of serious side effects from corticosteroids.
How similar studies have performed: Previous research has shown promise in using genetic information to predict treatment responses in various conditions, suggesting that this approach may yield valuable insights for asthma management.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAHLIN, AMBER — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: DAHLIN, AMBER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.