Understanding how genetic variations interact and affect traits
Toward a mechanistic understanding of genetic interactions
['FUNDING_OTHER'] · UNIVERSITY OF WASHINGTON · NIH-11093449
This study is looking at how different genes work together to affect health and how long we live, using tiny organisms like yeast and worms, to help figure out which genetic combinations are most important for understanding diseases and traits that matter to people.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11093449 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between genetic variants that contribute to traits and diseases. By using model organisms like yeast and the worm C. elegans, the study aims to identify significant genetic interactions that impact health and longevity. The approach involves advanced techniques such as high-throughput phenotyping and mapping populations to analyze how variations in DNA, particularly in repetitive elements, influence various phenotypes. This work seeks to prioritize which genetic combinations are most impactful for further study.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or those interested in the genetic basis of complex traits.
Not a fit: Patients without genetic variations or those not affected by complex traits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding of genetic diseases and inform personalized treatment strategies.
How similar studies have performed: Other research has shown success in understanding genetic interactions using model organisms, indicating that this approach is promising.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QUEITSCH, CHRISTINE — UNIVERSITY OF WASHINGTON
- Study coordinator: QUEITSCH, CHRISTINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease