Understanding how genetic variations influence health and disease
Coevolution and Functional Interactions in the Non-Coding Genome
This study is looking at how differences in our genes can affect our health, and it aims to help patients understand how their unique genetic makeup might influence their health and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10874702 on NIH RePORTER |
What this research studies
This research investigates how variations in the genome affect its function and influence health outcomes. By utilizing advanced computational methods and 3D genomic data, the project aims to predict the impact of unknown genomic variants on gene transcription and overall phenotype. The researchers will analyze the spatial organization of DNA to uncover functional interactions among genetic elements, which could lead to better understanding of diseases. Patients may benefit from insights gained about their genetic makeup and its implications for health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known genetic variations or those at risk for genetic disorders.
Not a fit: Patients with no identifiable genetic variations or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved predictions of health risks based on individual genetic variations.
How similar studies have performed: Other research has shown promise in using computational methods to link genomic variations to health outcomes, indicating a potential for success in this approach.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Di Pierro, Michele — Northeastern University
- Study coordinator: Di Pierro, Michele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.