Understanding how genetic variations in HLA affect health and immunity
The landscape of HLA mediated variation in health and immunity
This study is looking at how differences in certain genes related to the immune system might affect health and how our bodies respond to infections, and it's for anyone interested in understanding the links between genetics and conditions like autoimmune diseases and cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11083099 on NIH RePORTER |
What this research studies
This research investigates the role of Human Leukocyte Antigen (HLA) variations in influencing health and immune responses. By utilizing high-quality HLA genotyping data from over 100,000 individuals, the study aims to uncover the connections between specific genetic variations and various health conditions, including autoimmune diseases and cancers. Participants will provide self-reported health histories, which will be analyzed alongside their genetic information to identify potential genotype-phenotype associations. The research also focuses on how HLA variations impact antibody responses to infections like cytomegalovirus (CMV).
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a diverse range of health conditions, particularly those related to autoimmune diseases and cancers.
Not a fit: Patients who do not have any known autoimmune conditions or cancers may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of how genetic factors influence disease susceptibility and immune responses, potentially guiding personalized medicine approaches.
How similar studies have performed: Previous research has shown promising results in understanding HLA variations and their associations with diseases, indicating that this approach has the potential for significant insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Hollenbach, Jill Allison — University of California, San Francisco
- Study coordinator: Hollenbach, Jill Allison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.