Understanding how genetic variations in ALDH1L1 affect glycine metabolism
Mechanistic and metabolomic underpinnings of ALDH1L1 polymorphisms in the regulation of glycine metabolism
This study is looking at how a specific enzyme affects the way your body processes folate and glycine, especially in Hispanic children, to see if genetic differences might change how these nutrients are used, which could help us understand more about health and nutrition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10885036 on NIH RePORTER |
What this research studies
This research investigates the role of the ALDH1L1 enzyme in folate metabolism and its impact on glycine levels in the body. By studying genetic variations (polymorphisms) in the ALDH1L1 gene, the research aims to understand how these variations influence glycine metabolism, particularly in children from different ethnic backgrounds. The approach includes analyzing serum levels of glycine and related metabolites in a cohort of Hispanic children to identify potential metabolic disruptions. The findings could lead to insights into how genetic factors affect nutrient metabolism and overall health.
Who could benefit from this research
Good fit: Ideal candidates for participation include children, particularly those of Hispanic descent, who may carry specific genetic variations in the ALDH1L1 gene.
Not a fit: Patients who do not have the relevant genetic polymorphisms or who are not within the targeted age group may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into personalized dietary recommendations and interventions for individuals with specific genetic profiles affecting glycine metabolism.
How similar studies have performed: Previous research has shown that genetic variations can significantly impact metabolic pathways, suggesting that this approach may yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Krupenko, Sergey a — Univ of North Carolina Chapel Hill
- Study coordinator: Krupenko, Sergey a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.