Understanding how genetic variations contribute to Alzheimer's disease
Alzheimer variants: Propagation of shared functional changes across cellular networks
This study is looking at how different genes work together to influence Alzheimer's disease, helping us understand the disease better and potentially find new ways to treat it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11126418 on NIH RePORTER |
What this research studies
This research investigates the complex genetic factors that contribute to Alzheimer's disease by examining how different genetic variants interact within cellular networks. The approach involves analyzing combinations of genetic variants associated with Alzheimer's to understand their collective impact on disease pathology. By utilizing advanced molecular and epigenetic techniques, the study aims to create a comprehensive functional network that highlights critical interactions between these genetic factors. Additionally, a novel interface will be developed to integrate existing and new data, enhancing our understanding of Alzheimer's disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those diagnosed with early-stage Alzheimer's.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of Alzheimer's disease, potentially guiding the development of targeted therapies.
How similar studies have performed: Previous research has shown promise in understanding genetic interactions in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: De Jager, Philip L — Columbia University Health Sciences
- Study coordinator: De Jager, Philip L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.