Understanding how genetic variations at the amylase gene affect oral health.
Official title: Characterizing structural variation at the amylase locus influencing oral health
Funded at Harvard Medical School · NIH-10992311 · Data updated 2026-11-12
This study is looking at how our genes, especially the amylase gene, might affect our dental health and the likelihood of needing dentures, so if you're curious about how your genetics could influence your teeth and cavities, this research is for you!
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $44,003 |
| NIH project number | 1F31DE034283-01 |
| Project ID | NIH-10992311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are interested in understanding the genetic factors influencing their oral health.
✕Less likely to help
Patients with no interest in genetic factors affecting oral health or those who do not have dental health issues may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence oral health, particularly focusing on the amylase gene, which plays a role in dental caries and overall tooth health. By examining specific genetic variants associated with the need for dentures and their relationship with salivary amylase levels, the study aims to uncover how these genetic differences affect individuals' susceptibility to cavities. The research employs advanced genomic techniques to accurately assess the number of amylase gene copies in individuals, which is crucial for understanding their oral health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to personalized dental care strategies based on genetic profiles, improving oral health outcomes for many individuals.
How similar studies have gone: Previous studies have shown promising results in understanding genetic influences on dental health, indicating that this approach has potential for success.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Kamitaki, Nolan — Harvard Medical School
- Study coordinator: Kamitaki, Nolan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.