Understanding how genetic variations affect the 3D structure of the genome
Mapping heritable chromatin loop variants with allele-specific Hi-C analysis
This study is looking at how the structure of our genes is organized in 3D and how differences in our DNA can affect this setup, which might help us understand why some people develop conditions like adult-onset diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11012372 on NIH RePORTER |
What this research studies
This research investigates the complex 3D architecture of the mammalian genome and how genetic variations influence this structure. Using advanced techniques like Hi-C analysis, the study aims to create detailed maps of chromatin loops that connect important regulatory elements within the genome. By examining these relationships in specially bred mouse strains, researchers hope to uncover how genetic differences can lead to variations in gene expression and potentially impact health. This work could provide insights into the genetic basis of diseases such as adult-onset diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of adult-onset diabetes or related metabolic conditions.
Not a fit: Patients without any genetic predisposition to adult-onset diabetes or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how genetic variations contribute to diseases, potentially informing new treatment strategies.
How similar studies have performed: Previous studies using similar Hi-C techniques have shown promise in mapping genome architecture, suggesting that this approach could yield valuable insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Jin, Fulai — Case Western Reserve University
- Study coordinator: Jin, Fulai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.