Understanding how genetic variations affect oxytocin response during labor
Quantitative and computational characterization of oxytocin receptor signaling
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10636923
This study is looking at how certain genes might affect how well oxytocin works during labor for women, with the goal of helping doctors give the right amount of oxytocin to each patient for better health outcomes for both moms and babies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10636923 on ClinicalTrials.gov |
What this research studies
This research investigates how different genetic variations in the oxytocin receptor (OXTR) can influence a woman's response to oxytocin during labor. By analyzing specific gene variants, the study aims to develop a method to predict how effectively oxytocin will work for individual patients, which could lead to personalized dosing regimens. This approach addresses the significant variability in oxytocin response, which can impact both maternal and neonatal health outcomes. The research involves genetic analysis and clinical data to establish connections between OXTR variants and labor responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who are considering or require oxytocin for labor induction or augmentation.
Not a fit: Patients who are not pregnant or those who do not require oxytocin for labor will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective labor induction practices, reducing complications for mothers and newborns.
How similar studies have performed: Previous studies have shown promising results in linking genetic variations to drug responses, suggesting that this approach could be effective.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ENGLAND, SARAH K. — WASHINGTON UNIVERSITY
- Study coordinator: ENGLAND, SARAH K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.